With regard to periodontal inflammation it is noteworthy that tacrolimus, a synthetic calcineurin inhibitor like RCAN1, has been found to exert protective effects on periodontal disease progression [38, 39] indicating that “fine tuning” of the NFAT-RCAN1 negative feedback loops may modulate inflammatory process in periodontitis. The gene discussed is RCAN1; the disease is periodontal disorder.