IL6 and serum lipopolysaccharide activity: In addition, since intestinal disruption with DSS leads to bacteria translocation and systemic inflammation, we detected elevated IL-6 cytokine in serum (Figure 1(d)), together with a significant reduced endotoxemia in adrenalectomized mice exposed to DSS on day 6 (Figure 1(e)), suggesting an opposite role between systemic inflammatory responses and reduced LPS levels during colitis induction, in the absence of adrenal glands.