CCN4 and colitis: To further confirm the proinflammatory role of WISP1 in the pathogenesis of IBD and whether administration of rWISP1 could aggravate TNBS-induced colitis, we administered rWISP1 into BALB/c mice during TNBS-induced colitis and found that rWISP1 exacerbated intestinal inflammation, characterized by more weight loss, shorter colon length, and severe clinical features as well as higher pathological scores.