APC and hepatocellular carcinoma: Iyer et al. [25] detected the methylation statuses of APC, FHIT, p15, p16, and E-cadherin gene in 28 cases of HCC patients and found that methylated rates of these five genes in peripheral blood significantly and positively correlated with the methylated rates in tumor tissues and could well reflect the methylation status of abnormal genes in tumor tissues.