Twist1, a bHLH transcription factor, is a prototypical EMT inducer and a major regulator of invasion, metastasis, cancer stemness, and tumor initiation (Beck et al., 2015; Mani et al., 2008; Schmidt et al., 2015; Tsai et al., 2012; Yang et al., 2004). Here, TWIST1 is linked to neoplasm.