Depletion of ERRα using specific siRNAs in LRSKBr3 cells induces the downregulation of genes controlling cancer signalling along with various metabolic functions, including amino-acid metabolism, acetyl-coA biosynthesis, oxidative stress response, detoxification and regulation of glutamate, cysteine and methionine metabolism (Fig. 3j, right panels) (Supplementary Table 4). Here, ESRRA is linked to cancer.