It is of interest to note that previously we have shown that CgA-deficient Chga-KO mice also suffer from persistent systematic stress due to increased secretion of catecholamines compared with WT mice, which leads to hypertension and also demonstrates majority of the morphological changes that are observed in the hypersympathetic state observed in the HF condition in this study (Pasqua et al. 2016). This evidence concerns the gene CGA and hypertensive disorder.