Furthermore, integrative analysis of genetic interaction network and transcriptome revealed that IXR1, which encodes the protein binding the major DNA adducts of the antitumor drug cisplatin that is used in adjuvant chemotherapy for non-small-cell lung cancer [31], was among the first neighbours of ATX1 and down-regulated in the ATX1 deleted cells irrespective of the copper level in comparison to the reference strain. This evidence concerns the gene ATOX1 and non-small cell lung carcinoma.