In a few cases, mutant alleles of binding partners have been shown to modify the tumor phenotype associated with mutant RB1 alleles (Yamasaki et al. 1998; Ziebold et al. 2003; Lasorella et al. 2005; Parisi et al. 2007; Wang et al. 2010; Sun et al. 2011). This evidence concerns the gene RB1 and neoplasm.