Very recently, results from a K14-IL-17Aind/+ mouse model with keratinocyte overexpression of IL-17A were published and these animals developed very severe psoriasis-like skin lesions and displayed increased vascular oxidative stress, endothelial dysfunction, hypertension, left ventricle hypertrophy, and markedly reduced survival as compared to controls [15]. This evidence concerns the gene KRT14 and endothelial dysfunction.