In the unadjusted Cox analysis, treatment with an immunosuppressive agent, baseline cardiovascular diseases, higher GAP stage (≥II), higher serum SP-D level (≥194.7 ng/mL), and a higher eosinophil percentage in BAL fluid samples (≥3.21 %) were predictors of an AE-IPF (HR [95 % CI], 3.35 [1.27–8.84], 2.49 [1.00–6.19], 3.88 [1.54–9.80], 3.17 [1.21–8.31], and 3.27 [1.29–8.29], respectively). This evidence concerns the gene SFTPD and idiopathic interstitial pneumonia.