According to the ROC curve analysis, the optimum cut-off levels to predict an AE-IPF were 180 U/L for LDH, 946 U/mL for KL-6, 194.7 ng/mL for SP-D; and 10.15 1.77 and 3.21 % for lymphocyte, neutrophil, and eosinophil percentages in BAL fluid samples, respectively. Here, SFTPD is linked to idiopathic pulmonary fibrosis.