The directly LPS-induced genes that are known to be important during activity-regulated processes in PM include LRR and PYD domain-containing protein 3 (NLRP3), which is involved in inflammasomes in MS [52]; caspase (CASP)1; CASP4, which plays a critical role in the processing and secretion of proinflammatory molecules [53]; and PELI1, which is highly expressed in microglia and plays a key role in microglial activation during EAE induction [54]. The gene discussed is PELI1; the disease is myeloid sarcoma.