Whereas osteopontin-c did not improve as a predictor, the combination of high exon 4 intensity plus high tumor grade worsened the prognosis without hormone therapy (exon 4 alone hazard ratio 0.503, p-value 0.016; with grade 0.450, 0.007), but maintains the favorable prognosis under treatment (exon 4 alone 0.657, 0.131; with grade 0.763, 0.352). The gene discussed is SPP1; the disease is neoplasm.