Indeed, a previous study of the effect of PADI2 on oestrogen receptor-mediated transcriptional regulation showed that it regulated over 200 transcripts in those conditions.27 Future work will focus on defining more of these targets in BMMSCs in order to determine the broader implications of PADI2 in the transformation of the healthy BM to that of MGUS/MM. The gene discussed is PADI2; the disease is Miyoshi myopathy.