Using an immortalised, non-transformed BMMSC line (HS5), we assessed the effect of siRNA-mediated reduction in PADI2 expression (Figure 4a) on the expression of IL-6, as well as other factors expressed by BMMSCs known to have a role in MM pathogenesis: CXCL12 and cMET. This evidence concerns the gene IL6 and Miyoshi myopathy.