PADI2 and Miyoshi myopathy: Pathway analysis of differentially expressed genes between disease and control groups demonstrated that the most prominent enriched signalling pathway was WNT (P=0.00012 and 0.00002 for MM vs control and MGUS vs control, respectively; Supplementary Tables 8 and 9 and Supplementary Figure 1a), which has been previously implicated in the pathogenesis of MM.32, 33, 34 In addition, within the top five upregulated transcripts in MGUS and MM was a member of the PADI family of enzymes, PADI2 (Figure 2a), which was upregulated over fivefold in both MGUS and MM patient BMMSCs.