Although NDRG2 is thought to be a potential tumor suppressor in breast cancer, tumorigenesis studies investigating the tumor suppressive role of NDRG2 were irrespective of intrinsic breast cancer subtypes or mainly focused on luminal or basal B breast cancer cell models in vitro [8,9,15,25] and in vivo [12]. The gene discussed is NDRG2; the disease is breast cancer.