On the other hand, among patients with CKD stage G3a or G3b in the current population, the correlation between FGF23 and α-Klotho was not significant; in addition, the association between α-Klotho and LVH among patients with CKD stage 3a and that between α-Klotho and low LVEF among patients with CKD stage 3b remained statistically significant after entering FGF23 as an additional covariate in multivariate logistic regression analyses. This evidence concerns the gene FGF23 and chronic kidney disease.