In ROC curve analysis for the prediction of low LVEF, addition of FGF23 to the combination of age, sex, and eGFR significantly improved the prediction of LVH for patients with CKD stages G1-G4 (Fig 5D), but was not statistically significant in the subgroup of patients with CKD stage G1/G2 (Fig 5E) or G3-G4 (Fig 5F). This evidence concerns the gene FGF23 and chronic kidney disease.