In the current study, we found that lower α-Klotho levels were not associated with cardiac hypertrophy or systolic dysfunction among patients with CKD G1/G2 (Table 4); on the other hand, the lowest α-Klotho tertile was significantly associated with LVH and low LVEF among patients with CKD stage G3a and those with CKD stage G3b, respectively (Table 4). This evidence concerns the gene KL and cardiac hypertrophy.