In the current study, we found that lower α-Klotho levels were not associated with cardiac hypertrophy or systolic dysfunction among patients with CKD G1/G2 (Table 4); on the other hand, the lowest α-Klotho tertile was significantly associated with LVH and low LVEF among patients with CKD stage G3a and those with CKD stage G3b, respectively (Table 4). The gene discussed is KL; the disease is chronic kidney disease.