In fact, when subjects with a CKD stage of G2, G3, or G4 were analyzed together in the current study, α-Klotho was not significantly associated with LVH (odds ratio 1.31, 95% CI 0.84–2.03, P = 0.230) or low LVEF (odds ratio 1.06, 95% CI 0.63–1.85, P = 0.849) by model 5 used in Table 4. The gene discussed is KL; the disease is chronic kidney disease.