In ROC curve analysis for the prediction of LVH, addition of FGF23 (Fig 5A, 5B and 5C; model 2, red line) to the combination of age, sex, and eGFR (model 1, green line) significantly improved the prediction of LVH among patients with CKD stages G1-G4 (Fig 5A), G1/G2 (Fig 5B), and G3-G4 (Fig 5C), and this improvement seemed to be most prominent among those with CKD stage G1/G2. The gene discussed is FGF23; the disease is chronic kidney disease.