Nivolumab (Opdivo) an anti PD-1 mAb and fully human IgG4, approved by the FDA in 2014 for the treatment of malignant melanoma progressing after treatment with ipililumab or after treatment with serine/threonine protein kinase B-Raf (BRAF) inhibitor [67,68,69,70]. Here, BRAF is linked to melanoma.