Figure 1 shows that cells deficient in FANCD2, a critical DNA repair protein of the Fanconi Anemia pathway, are hypersensitive to the cytotoxicity of caffeic acid and coffee. This suggests that coffee and caffeic acid cause more DNA damage in cells deficient in this DNA repair protein. Figure 2 shows that cells lacking FANCD2 developed higher levels γ-H2AX foci than non-deficient cells when exposed to coffee and caffeic acid. This evidence concerns the gene H2AX and Fanconi anemia.