Studies show that the activation of LXRα, one of the LXRs, attenuates the atherosclerosis formation by an increase in expression of cholesterol efflux transporters ABCA1 and ABCG1 in macrophages [21], and excretion transporters ABCG5 and ABCG8 in enterocytes [22]. The gene discussed is ABCG8; the disease is atherosclerosis.