r = 0.343, p = 0.017), MMP-3 (r = 0.422, p = 0.003), TIMP-2 (r = 0.362, p = 0.011), and TIMP-4 (r = 0.506, p < 0.001) showed significant correlations with age for our MDS patients. This evidence concerns the gene TIMP4 and myelodysplastic syndrome.