Intriguingly, although we previously found that Gfi1 is among the earliest target genes bound and up-regulated by RUNX1b, the isoform of RUNX1 expressed in HE, the ontology of RUNX1b regulated genes in early HE revealed an upregulation of the expression of genes involved in angiogenesis, cell adhesion and migration.63,72. This evidence concerns the gene RUNX1 and hereditary elliptocytosis.