CDH3 is a calcium-sensitive cell adhesion molecule that plays a role in cell growth and differentiation.[18,19] CDH3 is overexpressed in the majority of pancreatic cancer and in various other malignancies, including bile duct, gastric, and colorectal cancers.[14,20–22] CDH3 overexpression was reported to be associated with an aggressive phenotype and poor prognosis of endometrial carcinomas.[18] In this study, CDH3 mRNA was significantly highly expressed in malignant biliary strictures and was a good predictor of malignant biliary stricture. This evidence concerns the gene CDH3 and colorectal cancer.