According to Table 4, study Buch2008 involved 100% of patients with insulin-treated T2DM in the SES and non-SE DES groups, whereas study Kedhi2012 reported 45% of patients in the SES group who were on insulin therapy and 42% patients in the non-SE DES group treated by insulin therapy. The gene discussed is INS; the disease is type 2 diabetes mellitus.