Studies showed that higher fat intake was linked to increased plasma estradiol, insulin secretion and IGFs levels, and inflammation markers (including hs-C-reactive protein, intercellular adhesion molecule-1, and interleukin-6), which illustrated that dietary fat intake may promote endometrial cancer development through unbalanced hormone, insulin and IGFs, and inflammation systems.[7–11] These evidences suggest a possible influence of dietary fat intake on endometrial cancer risk, but to date, there is no conclusive results for the associations between fat intake and endometrial cancer risk. The gene discussed is INS; the disease is endometrial cancer.