INS and type 2 diabetes mellitus: With respect to the influences of glucometabolic parameters on urinary NAG, it was reported that increased urinary NAG excretion was present in patients with poorly controlled glycemia.[29,30] Furthermore, a decrease in urinary NAG excretion could be achievable in patients with T2DM after intervention of short-term intensified glycemic control.[14] In this study, we demonstrated that stimulated glucose, GA, and decreased insulin secretory function predicted the diabetic renal tubulopathy assessed by urinary NAG.