Criteria vary among different authors with some of them having used the metabolic syndrome components (as hyperglycemia, dyslipidemia, high blood pressure)[8] as part of the definition, whereas others have included insulin resistance and/or ultrasensitive C-reactive protein (CRP), a marker of inflammation linked to cardiovascular risk.[10] Moreover, controversy still exists regarding the transitory nature of metabolically healthy status (MHS) in overweight and obese individuals.[4,9] In fact, normal weight individuals can also have an unhealthy metabolic profile.[11]. The gene discussed is CRP; the disease is Hyperglycemia.