The term “metabolically equipoised” might be more appropriate, as the absence of cardiometabolic dysfunction can be transitory.[6,20] Criteria that include biomarkers of insulin resistance (insulin, HOMA-IR) and inflammation (CRP), though theoretically more accurate, have the downside of being based on subjective cut-offs, so that each population sample will exhibit diverse values. Here, INS is linked to Insulin resistance.