CD4 and Cachexia: Patients stating ART with an advanced disease stage as defined by WHO stage 4 had an increasing risk of immune reconstruction syndrome and death.[9] TB and wasting syndrome appeared to be the most common causes of early mortality.[19] We should prevent and manage opportunistic infections such as TB, and offer better pre-ART care to reduce early death of patients with HIV/AIDS receiving ART, especially among patients with CD4 cell counts <200 cells/mm3.