Our results are in accordance with immunohistopathological results of CYP2R1 and CYP27A1 staining on biopsied liver tissues from CHC patients by Barchetta et al[31] and Petta et al.[32] Moreover, CYP24A1, an enzyme for degrading active form of vitamin D, was significantly upregulated in cirrhotic patients. This evidence concerns the gene CYP24A1 and cryohydrocytosis.