The studies have confirmed that PDCD5 also suppresses tumorigenesis by inhibiting the Ras/Raf/MEK/ERK signaling pathway in the human osteosarcoma cell line MG-63 (Han et al. 2012) and adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell lines (Xie et al. 2009). The gene discussed is PDCD5; the disease is osteosarcoma.