Jiang et al. formulated a pH- and thermo-sensitive nanogel as a dual MRI and fluorescence agent for medical imaging of brain glioma (Fig. 3).66 Fe3O4 was encapsulated in p(NIPAM-co-AA) (PNA), and the resulting nanogels were further conjugated with Cy5.5-labeled lactoferrin for fluorescence and tumor targeting. The gene discussed is LTF; the disease is brain glioma.