Consistent to this notion, in AD pathology, the accumulation of APs composed of Aβ aggregates and neurofibrillary tangles NFTs composed of misfolded Tau proteins, accumulation of these proteins as consequence of faulty protein quality control mechanisms, is associated with a deficit in those mechanisms participating to induction of cytoprotective proteins (Hsps) or, more in general, involved in the cellular pathways of stress tolerance. The gene discussed is MAPT; the disease is Alzheimer disease.