FCGR2A and dengue disease: The concept was confirmed in studies of serum samples from dengue patients, in which neutralizing activity was present to several DENV serotypes using non-FcγR-expressing cells, but ADE activity that lowers the overall neutralizing activity was present to the current infecting serotype (DENV-1 and DENV-3), as demonstrated by FcγR-expressing cells (Table 1) [17].