RB1 and cancer: The majority of known driver gene amplifications (e.g., EGFR, ERBB2, MET, and MYC) and homozygous deletions (e.g., CDKN2A, PTEN, and RB1) were captured, with 320 RACSs (38%) containing at least one known putative cancer driver gene, in addition to 531 RACSs (62%) without known driver genes.