Transgenic mice expressing ovine PRNP (Tg338) or cervid PRNP (TgElk) underwent intracerebral inoculation with brain homogenate from goats or a sheep with naturally acquired scrapie (G3538, G3558, G3953, G30-75 or S3178) and were monitored for the development of clinical signs associated with TSE disease (Bruce et al., 2004). The gene discussed is PRNP; the disease is human prion disease.