CD274 and neoplasm: Furthermore, Herbst et al. [22] reported the association of PD-L1 expression in tumor-infiltrating immune cells with the response to an anti-PD-L1 monoclonal antibody, MPDL3280A, in which 83 % of IHC 3+ NSCLC cases showed a response, whereas the response rate was less than 20 % in IHC 0–1+ cases.