In the present study, employing RT-qPCR and Western blotting, we found significantly lowered levels of CTGF transcript (p < 0.0000001) and protein (p < 0.0000001) in lung cancerous tissues compared with adjacent histopathologically unchanged tissues obtained from 98 patients with NSCLC (Fig. 1a–c). This evidence concerns the gene CCN2 and non-small cell lung carcinoma.