Therefore, an elevation of the CTGF expression could be of benefit at least in NSCLC, as in other malignancies CTGF was shown to be a hypoxia-responsive gene leading to an enhancement of cancer cells invasion (Kondo et al. 2002, 2006; Braig et al. 2011; Eguchi et al. 2013). Here, CCN2 is linked to non-small cell lung carcinoma.