CCN2 and non-small cell lung carcinoma: However, to the best of our knowledge, this is the first report indicating 5-dAzaC and TSA-induced over-expression of CTGF in NSCLC cells, although our findings suggest that 5-dAzaC induces the expression of CTGF in A549, Calu-1 and Beas-2B cells without altering the methylation status of its regulatory region.