F5 and Other metabolic disease: According to the results of laboratory tests, the neuroinfection, TORCH (toxoplasmosis–other–rubella–cytomegalovirus–herpesviridae) infections, coagulation disorders and trombocytopenia, metabolic disorders, and selected genetic abnormalities (factor V Leiden 1601G > A polymorphism and MTHFR 677C > T; 1298A > C polymorphisms) were excluded.