Interestingly, an increasing number of investigations have shown that naturally flavonoids (e.g. honokiol, kaempferol, galangin, quercentin, luteolin) were potent PPARγ agonists and have been known as attractive drug candidates for the therapy or prevention of T2DM with fewer unwanted side effects [13–17]. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.