Here, our study found that APL could improve insulin resistance which was approved by the following evidences: 1) APL treatment had notably beneficial effects on enhance glucose uptake capability in the models of skeletal muscle insulin resistance induced by palmitate; 2) APL treatment up-regulated of p-IRS-1 and p-Akt proteins which are involved in insulin- signaling pathways. The gene discussed is IRS1; the disease is Insulin resistance.