CASR and hypertensive disorder: Increased [Ca2+]o induces the binding of Ca2+ to the CaSR and activates the G-protein-phospholipase C(PLC)-inositol 1,4,5-trisphophate (IP3) receptor pathway, triggering an elevation in intracellular Ca2+ concentrations ([Ca2+]i), which is implicated in the development of cardiovascular diseases such as hypertensive disorders.