Notably, this CSC-induced shift seemed to be more pronounced in tumor-bearing (Fig 6G) compared to tumor-free mice (Fig 6E), as indicated by a CSC-induced increase in CD11b+, PMN-MDSC, and MO-MDSC cells (13.5%, 9%, and 4.8% in tumor-bearing versus 4.8%, 2.5%, and 1.5% in tumor-free mice). Here, ITGAM is linked to neoplasm.