For instance, SMARCB1 (INI1/SNF5/BAF47) is a subunit of the SWI/SNF complex that is lost in nearly all rhabdoid tumors, creating an oncogenic dependency on the PRC2-EZH2 methyltransferase, and sensitizing these tumors to small molecule inhibitors of EZH2 both in vitro and in vivo [6, 7]. Here, SMARCB1 is linked to rhabdoid tumor.