EZH2 and neoplasm: However, unlike in the Fuji xenograft model, EZH2 inhibition did not lead to a decrease in tumor growth (Fig 3C), although H3K27Me3 levels were found to be inhibited in tumors collected at study end (S3 Fig), and these cells were growth inhibited with tazemetostat in vitro (Fig 1B and 1D).