In contrast to the invariance of LOXL1, Fibulin-5 expression in the XFS-TFs (Fig 2B, 2D and 2F) was 7.0-fold (p = 0.02) and 10.8-fold +/- 1.0 (p = 0.03) higher than in the POAG or young no glaucoma controls, respectively (Fig 2H). Here, FBLN5 is linked to open-angle glaucoma.