The percentage of positive cells were 81.67 ± 3.51% in HepG2 cells and 37.67 ± 1.53% in L-02 cells (P < 0.05), suggesting a significant higher transfection efficiency of CMBsαvβ3 in HepG2 cells than in L-02 cells.Besides HepG2 cells, CMBsαvβ3 transfection was detected in lung adenocarcinoma A549 cells and SK-Herp-1 HCC cells (Fig 4E and 4F). Here, HEY2 is linked to hepatocellular carcinoma.