As previous studies have reported that NF-κB served as a barrier for reprogramming.8 and inhibitors for apoptosis, DOT1L, LSD1 and HDAC were able to improve the reprogramming efficiency.9, 10, 11, 12 We wanted to know whether these signaling pathways played pivotal roles in T-ALL cell reprogramming. This evidence concerns the gene DOT1L and acute lymphoblastic leukemia.