Even in glioma-initiating cells or glioblastoma stem cells (GSCs)-a subpopulation of cells within malignant gliomas that are characterized by their self-renewal capacity, multilineage differentiation properties, high oncogenic potential, and resistance to standard therapies [10]- the levels of Cx43 are negligible [11, 12]. Here, GJA1 is linked to glioblastoma.