Our results showed that the antibody against HA precipitated HA-PTEN, Cx43, c-Src and Csk in glioma cells transfected with Cx43 but not in glioma cells that lacked Cx43 expression (C6-Ires) or in C6-Cx43 cells transfected with pSG5L, suggesting that restoring Cx43 to glioma cells promotes its binding to PTEN, c-Src and Csk in glioma cells. Here, PTEN is linked to central nervous system cancer.