GJA1 and central nervous system cancer: Interestingly, restoring Cx43 to glioma cells reduces c-Src activity by decreasing the active form of c-Src (c-Src phosphorylated at tyrosine 416; Y416 c-Src) and increasing the inactive form of c-Src (c-Src phosphorylated at tyrosine 527; Y527 c-Src) [19].