Recently, CX-5461 was reported to induce p53-independent G2 checkpoint and apoptosis mediated by the Ataxia telangiectasia mutated (ATM) and Ataxia telangiectasia and Rad3 related (ATR) kinase pathway in acute lymphoblastic leukemia [33, 34]. The gene discussed is TP53; the disease is acute lymphoblastic leukemia.