Transduction of human THP-1 leukemia cells with a lentiviral vector expressing a TKTL1-specific shRNA (THP-1KD) specifically downregulated TKTL1 (Figure 1A) but not TKT (changed by 4.0 ± 1.2%; n = 3; p = NS). This evidence concerns the gene TKTL1 and leukemia.