The association of LAPTM4B *2 allele with colon cancer prognosis is not consistent with recent reports including in hepatocellular [23], ovary [27], lung [23], breast cancer [25] and etc. In hepatocellular carcinoma, Yang et al indicated that LAPTM4B*2 was correlated with tumor recurrence, poor histopathological differentiation and also an independent prognostic factor. The gene discussed is LAPTM4B; the disease is malignant colon neoplasm.