The same tendency of LAPTM4B *1/1 and LAPTM4B *1 was observed in the colon discovery and testing cohorts of colon cancer (P = 0.0417 and 0.0444, P = 0.0254 and 0.0292, respectively) (Fig 2C–2F). The gene discussed is LAPTM4B; the disease is colonic neoplasm.