Furthermore, LAPTM4B genotype was a novel independent prognostic factor of OS for colon cancer (P = 0.004, HR = 0.432, 95% CI: 0.243–0.768), even in the colon discovery cohorts (P = 0.007, S2 Table), but not for rectal and esophageal cancer patients (P = 0.791, HR = 1.073, 95% CI: 0.638–1.804 vs. P = 0.998, HR = 1.000, 95% CI: 0.663–1.530, respectively). The gene discussed is LAPTM4B; the disease is malignant colon neoplasm.