One explanation might be: the diverse expression patterns or isoforms of LAPTM4B in epithelial cells might demonstrate the difference of LAPTM4B genotype in prognosis in colon cancer vs rectal and esophageal cancers; the other explanation might be: the 19-bp sequence may play an important role in transcriptional regulation such as binding with the transcription factors or non-coding linker RNA in different cancers. This evidence concerns the gene LAPTM4B and colonic neoplasm.