However, we did not find a marked relation between LAPTM4B genotypes or alleles and OS for rectal and esophageal cancer cases (P = 0.7418 and 0.8520 for various genotypes vs. P = 0.7669 and 0.9356 for different alleles, respectively) (Fig 3A–3D). The gene discussed is LAPTM4B; the disease is esophageal cancer.