Extending this studies into the non-tumorigenic human IL3-dependent M07e (Figure 4A) cells [35], overexpression of FGFR1 also led to IL3-independent growth in vitro and, when xenografted into NSG immunodeficient mice, led to the development of leukemia, unlike mice engrafted with M07e cells carrying the empty MIEG3 vector (Figure 4B and 4C). This evidence concerns the gene FGFR1 and leukemia.