We found that cases with high CRLF2 expression showed significantly shorter OS than cases with low CRLF2 expression in both B-ALL (13.0 months vs. 33.0 months, P = 0.017) and T-ALL (11 months vs. 32.0 months, P = 0.014) (Figure 1B and 1C). Here, CRLF2 is linked to acute lymphoblastic leukemia.