CRLF2 and acute lymphoblastic leukemia: High CRLF2 expression in B-ALL patients showed a significant association with higher median WBC (45.8 × 109/L vs. 19.4 × 109/L, P = 0.035) and a higher percentage of WBC ≥ 30 × 109/L (85.7% vs. 38.9%, P < 0.0001), which are markers of poor prognosis in B-ALL (Supplementary Table 1).